论文部分内容阅读
目的:探讨类风湿关节炎患者疾病活动与血清中白介素-20(IL-20)水平的关系。方法:用酶标记免疫吸附测定(enzyme-linked immunosorbent assay,ELISA)方法检测60例类风湿关节炎患者及30例正常对照者外周血血清中IL-20水平。分析IL-20水平与RA发病和类风湿因子(rheumatoid factor,RF)、C反应蛋白(C reactive protein,CRP)、血沉(erythrocyte sedimentation rate,ESR)及同期手X光片分期的相关性。结果:活动期类风湿关节炎患者外周血中IL-20水平明显高于正常对照组(P<0.01)。类风湿关节炎患者IL-20水平与其RF、CRP、血沉及同期手X光片分期无明显相关性(P>0.2)。结论:活动期类风湿关节炎患者外周血中IL-20水平明显高于正常对照组,但与RF、CRP、血沉及同期手X光片分期无明显相关性。IL-20可能参与类风湿关节炎的发病过程,提示需进一步研究。
Objective: To investigate the relationship between disease activity and interleukin-20 (IL-20) levels in patients with rheumatoid arthritis. Methods: Serum levels of IL-20 in 60 rheumatoid arthritis patients and 30 normal controls were detected by enzyme-linked immunosorbent assay (ELISA). The correlation between the level of IL-20 and the onset of RA, and the levels of rheumatoid factor (RF), C reactive protein (CRP), erythrocyte sedimentation rate (ESR) and hand X-ray films were analyzed. Results: The level of IL-20 in the peripheral blood of active rheumatoid arthritis patients was significantly higher than that of the normal control group (P <0.01). The level of IL-20 in rheumatoid arthritis patients had no significant correlation with RF, CRP, erythrocyte sedimentation rate and hand X-ray staging (P> 0.2). Conclusion: The level of IL-20 in peripheral blood of patients with active rheumatoid arthritis is significantly higher than that of normal control group, but there is no significant correlation with RF, CRP, erythrocyte sedimentation rate and hand X-ray stage. IL-20 may be involved in the pathogenesis of rheumatoid arthritis, suggesting further study.