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目的探讨粉尘螨滴剂对螨性过敏性紫癜(HSP)患儿的疗效及预后的影响。方法选择2005年10月-2007年10月在本院儿科门诊与病房治疗的2～15岁粉尘螨、屋尘螨呈阳性患儿100例,随机分为对照组和试验组,每组50例。对照组应用常规治疗(激素、维生素C、复方芦丁片、氯雷他定片);试验组在常规治疗的基础上再加用粉尘螨滴剂舌下含服治疗,从低剂量起逐步递增,每天1次,治疗1a,随访1a。采用SPSS11.4软件进行统计学分析。结果对照组和试验组患儿均无脱落病例,粉尘螨滴剂干预1a后2组患儿复发次数比较差异有统计学意义(P<0.01)。干预前2组患儿血清IgE、24h尿蛋白定量及高倍镜下尿红细胞数比较差异均无统计学意义(Pa>0.05),干预后2组患儿血清IgE、24h尿蛋白定量及高倍镜下尿红细胞数比较差异均有统计学意义(Pa<0.05)。结论舌下含服粉尘螨滴剂能有效减少儿童螨性HSP的复发,降低其肾脏损害的发生率,改善预后。
Objective To investigate the effects of dust mite drops on the efficacy and prognosis of mites allergic purpura (HSP). Methods From October 2005 to October 2007 in our hospital pediatric outpatient and ward treatment of 2 to 15-year-old dust mites, house dust mite-positive children 100 cases were randomly divided into control group and test group, 50 cases in each group . The control group was treated with routine therapy (hormone, vitamin C, compound rutin tablets and loratadine tablets). On the basis of conventional treatment, the experimental group was treated with sublingual administration of dust mite drops, gradually increasing from low dose , Once daily, treatment 1a, follow-up 1a. SPSS11.4 software was used for statistical analysis. Results There were no cases of shedding between the control group and the experimental group. There was significant difference in relapse frequency between the two groups (P <0.01). Serum IgE, 24h urinary protein and urinary red blood cell count at high magnification were not significantly different between the two groups before intervention (Pa> 0.05). Serum IgE, 24h urinary protein in the two groups after intervention were quantified and at high magnification Urinary red blood cell count were statistically significant differences (Pa <0.05). Conclusion The sublingual dust mite drops can effectively reduce the relapse of mite HSP in children, reduce the incidence of renal damage and improve the prognosis.