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甘草甜素与甘草次酸能防治实验性肝硬化的发生,而柴胡皂甙则无此作用。为了进一步明确抑制肝纤维增生的机理,本文对其防治大白鼠实验性肝硬化的作用进行了进一步研究。结果表明,甘草甜素可明显阻止四氯化碳中毒大白鼠SGPT活力的升高,而其它二药则不明显。甘草甜素与柴胡皂甙能减少肝内甘油三酯的蓄积。病理组织学观察发现,经甘草甜素、甘草次酸治疗的大白鼠其肝损伤均较对照组为轻。组织化学观察显示,甘草次酸治疗的大白鼠肝糖原明显增多。甘草甜素与甘草次酸组的血清胎甲球蛋白检出率也高于对照组。实验结果提示,此三种药物无胶原溶解与重吸收的作用。
Glycyrrhizin and glycyrrhetinic acid can prevent the occurrence of experimental liver cirrhosis, while saikosaponin has no such effect. In order to further clarify the mechanism of the inhibition of hepatic fibrosis, the effects of prevention and treatment of experimental liver cirrhosis in rats were further studied. The results showed that glycyrrhizin could significantly prevent the increase of SGPT activity in carbon tetrachloride poisoned rats, while the other two drugs were not obvious. Glycyrrhizin and saikosaponin can reduce the accumulation of triglycerides in the liver. Histopathological observations revealed that rats treated with glycyrrhizin and glycyrrhetinic acid had lighter liver damage than the control group. Histochemical observations showed that there was a significant increase in liver glycogen in rats treated with glycyrrhetinic acid. Glycyrrhizin and glycyrrhetinic acid group serum fetoprotein detection rate was also higher than the control group. The experimental results suggest that the three drugs have no effect of collagen dissolution and reabsorption.