维生素D同钙一样能防止直结肠癌形成,因为维生素D能减少上皮细胞增生并诱导分化。尽管由于其影响钙代谢而致使其在治疗学上的应用受到限制,但其类似物如calcipotriol极少产生高钙血症。作者应用细胞分裂完全抑制技术和免疫组织化学技术研究1,25(OH_2)D_3、维生素D_2及calcipotriol对人直肠粘膜和结肠癌细胞线细胞增生的影响。 Vitamin D, like calcium, can prevent the formation of colon cancer, because vitamin D can reduce epithelial cell proliferation and induce differentiation. Although its use in therapeutics is limited due to its effect on calcium metabolism, its analogues such as calcipotriol rarely produce hypercalcemia. The authors studied the effects of 1,25(OH_2)D_3, vitamin D_2, and calcipotriol on the proliferation of lineage cells in human rectal mucosa and colon cancer cells using a technique of complete cell division and immunohistochemistry.