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对银杏细胞培养物胞内多糖(ICP)和胞外多糖(ECP)以及银杏叶多糖(LGP)进行药理活性测试。方法:采用常压密闭、低压密闭、断头及结扎双侧颈总动脉(带迷走神经)等方法,观察ICP和IGP对缺氧小鼠的影响;采用巴豆油致耳肿胀和醋酸致毛细血管通透性增加等方法,观察ECP和LGP对致炎小鼠的影响。结果:ICP与LGP可显著延长缺氧小鼠的存活时间;ECP与LGP可显著抑制致炎剂引起的小鼠耳肿胀和毛细血管通透性增加。结论:ICP和LGP对缺氧小鼠具有保护作用,ECP和LGP对致炎小鼠具有抗炎作用。
The pharmacological activities of ginsenosides (ICP), extracellular polysaccharides (ECP) and ginkgo leaf polysaccharides (LGP) were tested. METHODS: The effects of ICP and IGP on hypoxic mice were observed using methods such as airtight, low-pressure sealing, decapitation, and ligation of bilateral common carotid arteries (vagus nerves); ear swelling caused by croton oil and capillarity induced by acetic acid were observed. Methods such as increased permeability were used to observe the effects of ECP and LGP on inflammatory mice. RESULTS: ICP and LGP significantly prolonged the survival time of hypoxic mice; ECP and LGP significantly inhibited the swelling of the ear and capillary permeability of mice caused by inflammatory agents. CONCLUSIONS: ICP and LGP have protective effects on hypoxic mice, and ECP and LGP have anti-inflammatory effects on inflammatory mice.