盐酸二甲双胍是双胍类降糖药,随着糖尿病患者人数增加,越来越多的患者选择盐酸二甲双胍作为治疗药物,盐酸二甲双胍及其缓释片的销售量逐年增加。盐酸二甲双胍属于BCS分类中Ⅲ类的药物,具有高溶解性、低膜通透性、吸收受膜通透性限制的特点。它在胃肠道的吸收并不完全,主要在小肠吸收,胃和大肠吸收甚微,生物利用度较低。随着一致性评价的开展,要求企业将自制产品与原研产品进行相应的一致性研究。而在不同介质中考察与原研产品的体外释放的一致性是最先需要开展的内容。本实验的目的是将自制不同羟丙甲纤维素来源的盐酸二甲 Metformin Hydrochloride is a biguanide hypoglycemic drug. As the number of diabetic patients increases, more and more patients choose metformin hydrochloride as the therapeutic drug. The sales of metformin hydrochloride and its sustained release tablets have been increasing year by year. Metformin Hydrochloride belongs to the class of drugs in the BCS classification and has the characteristics of high solubility, low membrane permeability, and limited absorption by membrane permeability. It is not completely absorbed in the gastrointestinal tract, mainly absorbed in the small intestine, stomach and large intestine little absorption, bioavailability is low. With the development of the consistency assessment, the enterprise is required to make the corresponding consistency research between the homemade products and the original research products. However, the consistency between the in vitro release and the original product in different media should be the first to be carried out. The purpose of this experiment is to make a different source of hypromellose hydrochloride