用理论线性溶剂化能关系建立了两类局部麻醉药物 (咪唑烷二酮类和苄醇类 )的结构—疏水性关系。结果表明 :分子的体积越大 ,两类化合物的亲脂性越强。另外 ,对咪唑烷二酮而言 ,分子的氢键碱度与其LogP值呈负相关 ,而苄醇类化合物的氢键酸度越大 ,对亲脂性越有利。 The structure-hydrophobic relationship of two classes of local anesthetics (imidazolidinediones and benzyl alcohols) was established using theoretical linear solvation energy relationships. The results showed that the larger the molecular volume, the stronger the lipophilicity of the two compounds. In addition, for the imidazolidinedione, the hydrogen bond basicity of the molecule is negatively correlated with its LogP value, while the greater the hydrogen bond acidity of the benzyl alcohol compound is, the better the lipophilicity is.