研究表明,人体实体肿瘤大多存在乏氧区域(根据目前氧电极法测定肿瘤组织中O2分压中位数≤10 mm Hg为乏氧)。这一区域的肿瘤细胞抵抗电离辐射的能力是含氧量正常的肿瘤细胞的2~3倍,其主要原因是减少了氧自由基对DNA增殖的损伤[1]。实体瘤乏氧是放疗失败的主要原因,克服乏氧所导致的放疗抵抗是提高肿瘤治疗效果的一个重要途径[1]。放疗增敏剂是肿瘤放射治疗的一个重要研究课题,它能提高肿瘤细 Studies have shown that most of the solid tumors in vivo exist hypoxic region (based on the current oxygen electrode method to determine the median O2 partial pressure in tumor tissue ≤ 10 mm Hg for hypoxia). Tumor cells in this region are capable of resisting ionizing radiation 2 to 3 times as much as normoxia. The main reason for this is the reduction of DNA damage caused by oxygen free radicals [1]. Hypoxia in solid tumors is the main reason for the failure of radiotherapy. Overcoming hypoxia-induced radioresistance is an important way to improve the therapeutic effect of tumors [1]. Radiotherapy Sensitizer is an important research topic of tumor radiotherapy, it can improve the tumor fine