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环孢素(Cs)与各种药物合用都可能加重其毒性。Goffin等报告1例肾移植患者,在应用小剂量Cs时并用甲基睾丸酮(甲睾酮)后,发生了严重的可逆性肝肾功能损害,并探讨其发生机理。患者男性,47岁,行肾移植术后23个月,当时未发生急性排斥反应,现连续应用Cs(3.7mg/kg/d)、强的松龙(7.5mg/d)和硫唑嘌呤(50mg/d)治疗。患者有HBsAg带毒史近20年,在肾移植后血清谷草转氨酶(GOT)和谷丙转氨酶(GPT)波动于正常和轻度升高之间。患者因阳萎而口服甲睾酮(15mg/d,分3次)治疗,治疗前血清胆红素
Cyclosporine (Cs) combined with various drugs may aggravate its toxicity. Goffin et al reported a case of renal transplant patients, and the use of small doses of Cs and methyl testosterone (methyltestosterone), the occurrence of severe reversible liver and kidney dysfunction, and explore its mechanism. A 47-year-old male underwent renal transplantation 23 months after acute rejection without CsA (3.7 mg / kg / d), prednisolone (7.5 mg / d) and azathioprine 50mg / d) treatment. The patient had a history of HBsAg poisoning for nearly 20 years, with fluctuations in serum aspartate aminotransferase (GOT) and alanine aminotransferase (GPT) between normal and mild elevation after kidney transplantation. Patients with impotence and oral administration of methyl testosterone (15mg / d, 3 times) treatment, serum bilirubin before treatment