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一、氨基糖苷类抗生素(AGs)的作用机理AGs对细菌的作用是损害细菌细胞膜,使细菌胞浆外漏;并作用于核糖体,阻抑蛋白质合成;这些效果都十分明显。最近作者等发现AGs可阻抑DNA的早期复制。因此AGs的作用是多方面的,究竟以哪一方面为主,还难以确定。AGs的主要作用点,有假说认为是在核糖体,但氯霉素类、大环内酯类、林可霉素类、四环素类抗生素,都是作用于核糖体,但都只有抑菌作用,为什么AGs却具有杀菌作用呢?这就必须从对核糖体作用以外的损害细胞膜,阻抑DNA早期复制等方面来寻找。(一)AGs转运系统AGs可能是通过离子结合而进入细菌表层。AGs带正电荷,
First, the mechanism of aminoglycoside antibiotics (AGs) AGs on the role of bacteria is to damage the bacterial cell membrane, so that the leakage of bacterial cytoplasm; and act on the ribosome, inhibiting protein synthesis; these effects are very clear. The authors recently found that AGs suppress early DNA replication. Therefore, the role of AGs is multifaceted, which one is the main, but also difficult to determine. AGs the main point of action, there are hypotheses that is in the ribosome, but chloramphenicol, macrolides, lincomycin, tetracycline antibiotics, are acting on the ribosome, but only antibacterial effect, Why AGs has a bactericidal effect? This must be from the role of ribosomes other than damage to the cell membrane, inhibition of early DNA replication and other aspects to find. (A) AGs transport system AGs may enter the bacterial surface by ion binding. AGs with a positive charge,