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目的进一步了解急性混合性白血病（ＡＭＬＬ）临床细胞、形态学及免疫学等特点。方法在对１２９例急性白血病（ＡＬ）全面检查及分析的基础上，对其中５例ＡＭＬＬ的临床细胞形态学、细胞化学及免疫表型等进行分析。结果５例ＡＭＬＬ在细胞形态学、细胞化学及免疫表型等方面均表现淋和髓二系特征。免疫表型除均同时表达淋和髓相关抗原外，还均表达ＨＬＡ－ＤＲ抗原。其中１例尚同时表达ＣＤ７和ＣＤ３４。３例在住院治疗观察中，发现对较强的针对淋系和髓系白血病的联合化疗反应差。结论分析ＡＭＬＬ临床、细胞形态学及免疫学等特点，对于ＡＭＬＬ的诊断和指导治疗均有重要意义
Objective To further understand the clinical features, morphology, and immunology of acute mixed leukemia (AMLL). Methods Based on the comprehensive examination and analysis of 129 cases of acute leukemia (AL), the clinical cytomorphology, cytochemistry and immunophenotype of 5 cases of AMLL were analyzed. RESULTS: Five cases of AMLL showed lymphatic and medullary lineage characteristics in terms of cell morphology, cytochemistry, and immunophenotype. In addition to immunophenotypic expression of both lepto- and myeloid-associated antigens, HLA-DR antigens were also expressed. In one case, CD7 and CD34 were also expressed simultaneously. In the observation of hospitalization in 3 cases, it was found that the combination chemotherapy for leukemia and myeloid leukemia was poor. Conclusions The clinical, cytomorphological and immunological characteristics of AMLL are analyzed and are of significance for the diagnosis and treatment of AMLL.