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目的:研究八珍泻心胶囊对血液透析患者微炎症状态的影响。方法:将65例维持性血液透析患者随机分为治疗组(33例)及对照组(32例),观察临床证候积分、C-反应蛋白、肿瘤坏死因子α、血红蛋白、血清白蛋白、血清前白蛋白等指标。结果:治疗组能明显改善临床证候积分,治疗前后比较,差异有显著性或非常显著性意义(P<0.05或P<0.01);对照组治疗前后比较,无统计学意义(P>0.05);两组治疗后比较,差异有显著性意义(P<0.05)。治疗组治疗前后CRP、TNF-α、Hb、ALB、PA比较差异有显著性或非常显著性意义(P<0.05或P<0.01);对照组治疗前后比较,无统计学意义(P>0.05);两组治疗后比较,治疗组明显优于对照组,差异有显著性或非常显著性意义(P<0.05或P<0.01)。结论:八珍泻心胶囊能改善血液透析患者微炎症状态,提高生活质量。
Objective: To study the influence of Bazhen Xuxin Capsule on the micro-inflammation status of hemodialysis patients. Methods: Sixty-five patients with maintenance hemodialysis were randomly divided into treatment group (n = 33) and control group (n = 32). Clinical syndrome scores, C-reactive protein, tumor necrosis factor alpha, hemoglobin, serum albumin, Pre-albumin and other indicators. Results: The treatment group could significantly improve the clinical syndrome score, and the difference was significant or very significant (P <0.05 or P <0.01) before and after treatment. There was no significant difference in the control group before and after treatment (P> 0.05) There was significant difference between the two groups after treatment (P <0.05). The difference of CRP, TNF-α, Hb, ALB and PA in the treatment group before and after treatment was significant or very significant (P0.05 or P0.01), but there was no significant difference in the control group before and after treatment (P0.05) ; After treatment, the treatment group was significantly better than the control group, the difference was significant or very significant (P <0.05 or P <0.01). Conclusion: Ba Zhen Xie Xin Capsule can improve the status of micro-inflammation in hemodialysis patients and improve the quality of life.