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目的 探讨肝细胞癌 (hepatocellularcarcinoma ,HCC)组织中血管生成与凋亡抑制蛋白bcl- 2和bcl-xl的关系及其临床意义。方法 对经病理证实的肝细胞癌 38例共 4 0个癌灶进行分析 ,用免疫组化SP法检测癌组织中血管内皮生长因子 (vascularendothelialgrowthfactor ,VEGF)、bcl-和bcl-xl的表达以及微血管密度 (microvsseldensity ,MVD) ,分析它们之间的相互关系 ,并将免疫组化的结果与患者的临床及手术、病理结果进行对照分析。结果 bcl- 2与bcl-xl明显相关 (P <0 .0 1) ,VEGF与bcl- 2之间也存在一定的相关性 (P <0 .0 5 ) ;在VEGF、bcl-xl的阴性和阳性表达组MVD均具有显著的差异 (P <0 .0 5 )。在不同的病理分级和病灶大小之间 ,bcl -xl表达的阳性率均具有显著差异 (P <0 .0 5 ) ;侵袭转移组、病理分级高以及无包膜 包膜欠完整的病灶的MVD明显高于无侵袭转移组、病理分级低以及包膜完整的病灶的MVD(P <0 .0 5 ) ;而VEGF阳性表达的病灶的包膜也倾向于无包膜 包膜欠完整 (P <0 .0 5 )。结论 VEGF和bcl -xl调控肿瘤的血管生成 ,凋亡抑制蛋白、VEGF和MVD共同影响HCC的临床病理特征。
Objective To investigate the relationship between angiogenesis and apoptosis-inhibiting protein bcl-2 and bcl-xl in hepatocellular carcinoma (HCC) and its clinical significance. Methods A total of 40 lesions of hepatocellular carcinoma confirmed by pathology were analyzed. Immunohistochemical SP method was used to detect the expression of vascular endothelial growth factor (VEGF), bcl- and bcl-xl, and microvessel Density (microvsseldensity, MVD), the relationship between them was analyzed, and the results of immunohistochemistry were compared with the clinical and surgical, pathological results of patients. Results There was a significant correlation between bcl-2 and bcl-xl (P <0.01). There was also a correlation between VEGF and bcl-2 (P <0.05) Positive expression of MVD were significantly different (P <0. 05). The positive rate of bcl-xl expression was significantly different between different histological grades and lesion size (P <0.05). In invasiveness and metastasis group, MVD was higher in pathological grading and less intact lesion (P <0.05), while the positive expression of VEGF in the lesion also tended to be less intact (P <0.05), which was significantly higher than that in the non-invasion and metastasis group, the low pathological grade and the complete lesion 0 .0 5). Conclusion VEGF and bcl-xl regulate the tumor angiogenesis, apoptosis-inhibitory protein, VEGF and MVD together affect the clinicopathological features of HCC.