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目的:探讨原发性高血压(EH)患者血浆中肾上腺髓质素前体N端20肽(PAMP)与左室肥厚的相互关系。方法:观察62例EH患者血浆PAMP的变化以及与左室重量指数之间的关系。结果:经超声心动图检查显示,62例EH患者中伴左室肥厚者42例,无左室肥厚患者20例。EH伴左室肥厚患者血浆PAMP浓度较无左室肥厚患者明显增高(65·8±12·0)∶(60·8±9·0)ng/L,P<0·05。结论:EH患者血浆PAMP的升高可能为机体的代偿反应,有助于改善患者的预后。
Objective: To investigate the relationship between plasma NADP20 peptide (PAMP) and left ventricular hypertrophy in patients with essential hypertension (EH). Methods: The changes of plasma PAMP and the relationship with left ventricular mass index in 62 EH patients were observed. Results: Echocardiography showed that in 62 patients with EH, there were 42 cases with left ventricular hypertrophy and 20 cases without left ventricular hypertrophy. The plasma PAMP levels in EH patients with left ventricular hypertrophy were significantly higher than those in patients without left ventricular hypertrophy (65.8 ± 12.0): (60.8 ± 0.9) ng / L, P <0.05. Conclusion: The elevation of plasma PAMP in patients with EH may be the compensatory response of the body and help to improve the prognosis of patients.