论文部分内容阅读
为研究涎腺粘液表皮样癌高转移细胞的药物敏感性特点，应用ＭＴＴ法测试了人涎腺粘液表皮样癌细胞系ＭＥＣ－１以及从其中分离出的细胞亚系Ｍｃ、低转移细胞株Ｍｃｌ、Ｍｃ２和高转移细胞株Ｍｃ３对１５种药物的敏感性。５种细胞对１５种药物的敏感性大体相似而又有差别。与Ｍ、Ｍｃ、Ｍｃｌ、Ｍｃ２相比较，Ｍｃ３对阿霉素、表阿霉素、氟脲嘧啶、长春新碱、维甲酸、干扰素的敏感性较强，对阿糖胞苷、补骨脂素、尼莫通的敏感性较低。研究结果符合肿瘤异质性的规律。
In order to study the drug sensitivity characteristics of high metastatic cells in mucoepidermoid carcinoma of the salivary glands, the human salivary gland mucoepidermoid carcinoma cell line MEC-1 and the subclones of cells isolated from it were tested by MTT. Mc, low metastatic cell line Mcl The susceptibility of Mc3, Mc2 and highly metastatic cell line Mc3 to 15 drugs. The sensitivity of the 5 cells to the 15 drugs was similar and different. Compared with M, Mc, Mcl and Mc2, Mc3 is more sensitive to doxorubicin, epirubicin, fluorouracil, vincristine, retinoic acid and interferon, and to cytarabine, psoralen The sensitivity of vegetarian and nimototon is low. The results are consistent with the laws of tumor heterogeneity.