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To compare stages IB1and IB2cervical cancers treated with radical hysterectomy (RH)and to define predictors of nodal status and recurrence.Patien ts with stage IB cervical cancers undergoing RH between 1990a nd 2000were e-valuated and clinicopathological v ariables were abstracted.The perioperative complication rate,estimated blood loss(EBL),and OR time were also tabulated.Variables were analyzed usingχ 2 and t tests.Disease -free survival(DFS)was calculated by Kaplan -Meier meth od.Multi-variate analysis was performed via s tepwise logistic regres-sion.Cox -proportional hazards were used to identify in-dependent predictors of recurrence.RH was performed on109stage IB1and 86stage IB2patient s.Mean age,EBL,and perioperative complication rates were similar.Overall,38patients(14IB1vs.24IB2)had positive nodes(P =0.01)including 9patients with positive p ara -aortic nodes(2IB1and 7IB2).Parametrial involvement (PI )and outer 2/3depth of invasion(DOI )were significantly more common in the IB2tumors as well.Patients with IB2dis-ease received adjuvant radiation mo re frequently than IB1patients(52%vs.37%,P =0.04).Univariate predic-tors of nodal status included lymphovascular space in-volvement (LVSI )(P =0.001),DOI (P =0.011),PI (P =0.001),and stage(P =0.011).Multivariate analysis identified only LVSI (OR 6.4,CI 2.4-17,P =0.0002)and PI (OR 8,CI 3.1-20,P =0.0001)as independent predictors of positive nodes.With a median follow -up of 35months,estimates of DFS revealed tumor size(P =0.008),nodal status(P =0.0004),LVSI (P =0.002),PI (P =0.004),and DOI (P =0.0004)as significant univariate predictors.Neoadjuvant chemothera-py,age,grade,histology,and adjuvant radiation were not associated with recurrence.The significant indepen-dent predictors of DFS were LVSI (ROR 5.7,CI 2-16,P =0.0064)and outer 2/3DOI (OR 5.8,CI 2-20,P =0.0029).Neither tumor size nor nodal status was a significant predictor of DFS.The pr ognosis in stage IB cervical cancer seems to be most infl uenced by presence of LVSI and DOI and not by tumor size as th e staging criteria would suggest.These factors are best determined patho-logically after radical hysterecto my.This report contains the largest comparison of IB1and IB2patients managed by RH.Tumor size failed to predict recu rrence or nodal status when stratified by LVSI,DOI,and PI.Treatment deci-sions based on tumor size alone shoul d be reconsidered.
To compare stages IB1 and IB2cervical cancers treated with radical hysterectomy (RH) and to define predictors of nodal status and recurrence. Patien ts with stage IB cervical cancers undergoing RH between 1990a nd 2000were e-valuated and clinicopathological v ariables were abstracted. The perioperative complication rate , estimated blood loss (EBL), and OR time were also tabulated. Variables were analyzed using 2 and t tests. Disease-free survival (DFS) was calculated by Kaplan-Meier meth od. Multi- variate analysis was done via s tepwise logistic regres-sion.Cox -proportional hazards were used to identify in-dependent predictors of recurrence. RH was performed on 109stage IB1and 86stage IB2patient s.Mean age, EBL, and perioperative complication rates were similar. Overall, 38patients (14IB1vs.24IB2) had positive (P = 0.01) including 9patients with positive p ara-aortic nodes (2IB1 and 7IB2). Parametrial involvement (PI) and outer 2 / 3depth of invasion (DOI) were significantly more common in the IB2 tumors as well. Patients with IB2dis-ease received adjuvant radiation mo re frequently than IB1patients (52% vs.37%, P = 0.04) .Univariate predic- tors of nodal status included lymphovascular space in-volvement (LVSI) ), DOI (P = 0.011), PI (P = 0.001), and stage (P = 0.011) .Multivariate analysis identified only LVSI (OR 6.4, CI 2.4-17, -20, P = 0.0001) as independent predictors of positive nodes. A median follow-up of 35months, estimates of DFS revealed tumor size (P = 0.008), nodal status (P = 0.0004), LVSI Age (P = 0.004), and DOI (P = 0.0004) as significant univariate predictors. Neojujujuvant chemothera-py, age, grade, histology, and adjuvant radiation were not associated with recurrence.The significant independent-predictors of DFS were LVSI ROR 5.7, CI 2-16, P = 0.0064) and outer 2 / 3DOI (OR 5.8, CI 2-20, P = 0.0029). Neither tumor size nor nodal status was a significant predictor of DFS. cervical cancer seems to be most infl uenced by presenceof LVSI and DOI and not by tumor size as th e staging criteria would suggest. These factors are best determined patho-logically after radical hysterectomy my.This report contains the largest comparison of IB1 and IB2patients managed by RH. Tumor size failed to predict recu rrence or nodal status when stratified by LVSI, DOI, and PI. Treatment deci-sions based on tumor size alone shoul d be reconsidered.