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目的:观察活血祛风通络法对类风湿关节炎患者治疗前后血液微循环指标变化的影响,探讨中医药在治疗RA过程中的作用机理。方法:将确诊的81例患者随机分为两组,对照组口服来氟米特片、洛索洛芬钠片治疗,治疗组在对照组用药的基础上,加服自拟活血祛风通络中药方剂。3个月为1个疗程。治疗前和1个疗程后分别应用增强型能量多普勒显像观察两组类风湿关节炎患者的手指指腹动脉的收缩期峰值速度(PSV)、舒张期峰值速度(EDV)以及血管阻力(RI)参数、血液流变学相关指标和临床症状的改变,并进行疗效评定。结果:①治疗组的总有效率为90.24%,明显高于对照组的75.00%(P<0.05)。②治疗组的临床症状及体征与对照组比较改善程度更明显。③治疗组的指腹微循环指标PSV、EDV、RI及血液流变学相关指标较对照组均有明显改善。结论:活血祛风通络法联合来氟米特片、洛索洛芬钠片能改善类风湿关节炎患者微循环障碍,治疗类风湿关节炎疗效肯定,且较单纯西医治疗更具优势。
Objective: To observe the effect of activating blood circulation Qufeng and meridians method on changes of blood microcirculation index in patients with rheumatoid arthritis before and after treatment, and to explore the mechanism of action of traditional Chinese medicine in the treatment of RA. Methods: The 81 patients diagnosed were randomly divided into two groups, the control group oral leflunomide tablets, loxoprofen sodium tablets treatment, the treatment group in the control group on the basis of medication, plus serving self blood Qufeng Tongluo Chinese medicine prescription. 3 months for a course of treatment. Before treatment and after one course of treatment, enhanced energy Doppler imaging was used to observe the peak systolic velocity (PSV), diastolic peak velocity (EDV) and vascular resistance (Vp) of finger finger artery in two groups of patients with rheumatoid arthritis RI) parameters, hemorheology related indicators and clinical symptoms, and evaluate the curative effect. Results: ① The total effective rate of the treatment group was 90.24%, which was significantly higher than that of the control group (75.00%, P <0.05). ② The clinical symptoms and signs of treatment group compared with the control group to improve the degree of more obvious. ③ The indexes of PSV, EDV, RI and hemorheology in the treatment group were significantly improved compared with the control group. Conclusion: Huoxue Qufeng Tongluo combined with leflunomide tablets, loxoprofen sodium tablets can improve microcirculation disorders in patients with rheumatoid arthritis, treatment of rheumatoid arthritis affirmation, and more advantages than Western medicine alone.