cAMP代谢和细胞增殖之间的关系。一般认为cAMP在细胞分裂中主要起负的调节剂作用,而报告起正作用却很少。本文报告鼠淋巴细胞在用促细胞分裂剂伴刀豆球蛋白A(ConA)刺激后cAMP变化的情况。结果表明cAMP在淋巴细胞DNA合成前有急剧的增减,而是细胞进入S期所必需的。 The relationship between cAMP metabolism and cell proliferation. It is generally believed that cAMP plays a major role as a negative regulator in cell division, but it is reported that there are few positive effects. This article reports on the changes of cAMP in murine lymphocytes following stimulation with the mitogen, concanavalin A (ConA). The results indicate that cAMP has a dramatic increase or decrease before lymphocyte DNA synthesis, but is necessary for cells to enter the S phase.