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白血病是造血干细胞来源的克隆性恶性肿瘤,现已发现大多数白血病都伴有染色体的改变,染色体异常与白血病的发生发展密切相关,一些特异性染色体异常不仅与白血病的FAB分型具有明显相关性,而且具有独立的预后价值。染色体畸变可作为监测急性白血病缓解、复发和CML急变的重要指标。1病例患儿女性,10岁,以“发热、咳嗽4天,发现血常规异常3天”入院。体查:神智清,精神一般。中度贫血貌,皮肤粘膜无黄染及皮疹,无明显出血点,浅表淋巴结未触及肿大。头型正常,结膜无充血,巩膜无黄染,口唇苍白。腹软无
Leukemia is a clonal malignant tumor derived from hematopoietic stem cells. It has been found that most leukemias are accompanied by chromosomal changes. Chromosomal abnormalities are closely related to the occurrence and development of leukemia. Some specific chromosomal abnormalities not only have obvious correlation with leukemia FAB typing , But also has an independent prognostic value. Chromosomal aberrations can be used as an important indicator to monitor acute leukemia, relapse and CML. A case of female children, 10 years old, with “fever, cough for 4 days and found abnormal blood 3 days ” admission. Physical examination: God clear, the spirit of the general. Moderate anemia, skin and mucous membrane without yellow dye and rash, no obvious bleeding, superficial lymph nodes did not touch swollen. Normal head, conjunctival hyperemia, sclera no yellow dye, pale lips. Abdomen soft