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西尼罗病毒的真面目及其基因内的“核心机密”西尼罗病毒属于虫媒病毒的黄病毒属的一个种,为单链 RNA 病毒,由二十面体核壳体包围,直径为21nm～35nm 的圆形颗粒,外有来自宿主细胞膜的糖蛋白 E,由一完整的包膜蛋白 E与膜蛋白联结。黄病毒基因为11000～12000核苷酸长,5′和3′端含有未编码的 NC区,基因编码10个蛋白,其中3个为结构蛋白(C,M,E)7个为非结构蛋白(NS1,NS2a,NS2b,NS3,NS4a,NS4b 和 NS5),M 蛋白是从其前体 prM 切割产生的。M 蛋白是高度疏水性的,可插入病毒颗粒的双
The true face of West Nile virus and its gene within the “core secret ” West Nile virus belongs to a species of flavivirus Arbovirus, single-stranded RNA virus, surrounded by icosahedral nuclear shell diameter of 21nm ~ 35nm round particles, outside the host cell membrane glycoprotein E, by a complete envelope protein E and membrane protein binding. The flavivirus gene is 11000-12000 nucleotides in length and contains uncoded NC regions at the 5 ’and 3’ end. The gene encodes 10 proteins, of which 3 are structural proteins (C, M, E) and 7 are non-structural proteins (NS1, NS2a, NS2b, NS3, NS4a, NS4b and NS5), the M protein is cleaved from its precursor prM. The M protein is highly hydrophobic and can double into viral particles