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目的研究基质金属蛋白酶抑制基因RECK在子宫内膜癌组织中和正常子宫内膜中的表达及其意义。方法选取中国医科大学附属盛京医院2003年1月至2006年12月43例子宫内膜癌患者行广泛子宫切除术的标本石蜡切片和同期20例子宫脱垂患者手术切除的正常子宫内膜标本石蜡切片,对组织RECK采用免疫组织化学法检测。结果①RECK在细胞膜表达,内膜癌组织中RECK阳性表达率为51%;对照组RECK阳性表达率为80%,差异有统计学意义(P<0.05)。②Ⅰ期的子宫内膜癌组织中RECK的表达阳性率明显高于Ⅲ期(P<0.05),而Ⅱ期与Ⅰ期比较差异无统计学意义(P>0.05)。Ⅱ期与Ⅲ期比较差异有统计学意义(P<0.05);子宫浅肌层浸润者RECK表达阳性率高于深肌层浸润者(P<0.05);子宫内膜癌病理分级间RECK表达差异无统计学意义;RECK在有淋巴转移和无淋巴转移组间比较差异有统计学意义(P<0.05)。结论①RECK在正常子宫内膜中广泛表达,在子宫内膜癌组织中表达明显降低或不表达。②RECK可抑制子宫内膜癌的发生、浸润和转移。
Objective To study the expression and significance of RECK in endometrial carcinoma tissue and normal endometrium. Methods A total of 43 cases of endometrial cancer patients undergoing radical hysterectomy from January 2003 to December 2006 in Shengjing Hospital of China Medical University were paraffin sectioned and 20 cases of normal endometrial specimens resected during the same period Paraffin sections, the tissue RECK detected by immunohistochemistry. Results ① The expression of REC in the cell membrane and the expression of RECK in the endometrial carcinoma were 51%. The positive expression rate of RECK in the control group was 80%, the difference was statistically significant (P <0.05). ② The positive expression rate of RECK in stage Ⅰ endometrial carcinoma was significantly higher than that in stage Ⅲ (P <0.05), but there was no significant difference between stage Ⅱ and stage Ⅰ (P0.05). (P <0.05). The positive rate of RECK in infiltrating myometrium was higher than that in deep myometrial infiltrating (P <0.05). The difference of RECK expression in pathological grade of endometrial carcinoma There was no significant difference between the two groups (P> 0.05). There was significant difference in RECK between lymphatic metastasis and non-lymphatic metastasis (P <0.05). Conclusion ① RET is widely expressed in normal endometrium and significantly decreased or not expressed in endometrial carcinoma. ②ECK can inhibit the occurrence, invasion and metastasis of endometrial cancer.