作者报告以低温保存的幼虫建立的感染,能使小鼠产生对再感染的抵抗力,还发现了接种大剂量照射过的和低温保存的童虫疫苗也能激发有效的保护作用。 15只CAB/Lac小鼠各肌肉注射1,700条未经照射、低温保存的曼氏血吸虫童虫,同时用10只未处理的对照鼠,8周后,用200条未经照射的同种尾蚴进行皮肤攻击感染。攻击感染后21天,在解剖回收时,最初经低温 The authors report that an infection established with cryopreserved larvae gave mice resistance to reinfection and also found that vaccination with large doses and cryopreserved Schistosoma vaccines could elicit an effective protective effect. Fifteen CAB / Lac mice were intramuscularly injected with 1,700 unmanaged, cryogenically conserved Schistosoma mansoni worms with 10 untreated control mice at the same time for 8 weeks and then treated with 200 non-irradiated cercariae of the same type Skin attack infection. Twenty-one days after challenge with infection, recovery was initially anatomized at low temperature