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磺胺是对氨基苯甲酸拮抗剂,有较强的广谱抗菌作用,细菌代谢与疟原虫代谢有许多相似之处,早在1937年Hill等就用百浪多息(Prontosil,Ⅰ)治疗疟疾病人,以后发现多种磺胺可以抑制疟原虫的生长与繁殖。2,4-二氨基-6-取代氨基喹唑啉衍生物(Ⅱ)对伯氏鼠疟原
Sulfanilamide is a p-aminobenzoate antagonist with a strong broad-spectrum antibacterial activity. Bacterial metabolism has many similarities with the metabolism of Plasmodium. As early as 1937, Hill et al. Used Prontosil (Ⅰ) to treat malaria patients , Later found that a variety of sulfonamides can inhibit the growth and reproduction of malaria parasite. 2,4-Diamino-6-Substituted Aminoquinazoline Derivatives (Ⅱ) Against Murine Plasmodium