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目的 探索多方法联合手术对不能手术切除的胰腺癌的治疗作用。方法 2 6例胰腺癌患者 ,胰头癌 17例 ,先行减黄手术 ,然后向肿瘤内注射无水酒精 ;肿瘤内置入后装机放疗管 ;胃十二肠动脉置入多功能药物化疗泵导管 ;肿瘤周围及基底部注入自配亚甲兰合剂。胰体癌 9例 ,除经脾动脉置入多功能药物化疗泵导管外 ,其余方法同胰头癌。术后 2周施行后装机内照射及经多功能药埋藏泵注入 5 - Fu、丝裂霉素。结果 全部病例无手术死亡 ,术后 2 d10 0 % (16 / 16 )患者疼痛减轻 ,疼痛完全消失 76 .8% (12 /16 ) ,维持时间最长 2 0个月。 2个月复查 ,B超、CT示肿瘤缩小率 10 0 %。半年存活率 10 0 % (2 6 / 2 6 ) ,1年存活率 80 .7% (2 1/ 2 6 ) ,中位生存期 13.6个月。结论 多方法联合手术治疗不能切除的胰腺癌有明显的治疗效果 ,特别对疼痛治疗有良好作用 ,明显提高了患者的生存质量。
Objective To explore the therapeutic effect of multi-method combined surgery on unresectable pancreatic cancer. Methods Twenty-six patients with pancreatic cancer and 17 patients with pancreatic head cancer underwent first reduction of yellow surgery and then injected into the tumor with anhydrous alcohol. After implantation of the tumor, a radiotherapy tube was installed. Gastroduodenal artery was infused with multifunctional drug- Peripheral and basilar tumors injected with self-made methylene blue mixture. Nine cases of pancreatic body cancer, in addition to the splenic artery catheterized multi-drug chemotherapy catheter, the remaining method with pancreatic cancer. After 2 weeks after operation, the rats were loaded with 5 - Fu and mitomycin by internal combustion and multifunctional medicine burial pump. Results All patients died without surgery. Pain was relieved in 10% (16/16) of patients 2 days after operation. The pain completely disappeared 76.8% (12/16) and the longest maintenance time was 20 months. 2 months review, B ultrasound, CT showed tumor reduction rate 10 0%. Half-year survival rate was 10 0% (2 6/2 6), 1-year survival rate was 80.7% (2 1/2 6), and median survival time was 13.6 months. Conclusion Multi-method combined with surgical treatment of unresectable pancreatic cancer has obvious curative effect, especially for the treatment of pain, and obviously improves the quality of life of patients.