论文部分内容阅读
目的 研究转化生长因子 β1(TGF- β1)在大肠腺瘤恶性转化过程中不同发展阶段的表达差异。方法应用免疫组化Envision法检测了55例大肠腺瘤标本中TGF- β1 的表达情况。结果 从轻度异型增生到癌变腺瘤 ,TGF- β1 的表达呈逐步减少的趋势 ,其中在中度和重度异型增生腺瘤中的表达有显著性差异 (P<0.05)。结论TGF- β1 分泌减少是大肠腺瘤向恶性转化的重要因素 ,TGF- β1 分泌的减少主要发生在大肠腺瘤从中度向重度异型增生发展的过程中。
Objective To study the expression of transforming growth factor-β1 (TGF-β1) in different stages of malignant transformation of colorectal adenoma. Methods Immunohistochemical Envision was used to detect the expression of TGF-β1 in 55 specimens of colorectal adenomas. Results From mild dysplasia to cancerous adenoma, the expression of TGF-β1 was gradually decreased, and there was a significant difference in the expression of moderate and severe dysplasia adenomas (P<0.05). Conclusion The decrease of TGF-β1 secretion is an important factor in the malignant transformation of colorectal adenomas. The decrease of TGF-β1 secretion mainly occurs in the progression of moderate to severe dysplasia of colorectal adenomas.