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组蛋白乙酰化在基因转录和表达方面具有关键作用,并与多种神经变性疾病的病理过程相关,因此,组蛋白去乙酰化酶抑制剂成为近年来的研究热点。本文概述了组蛋白去乙酰化酶抑制剂分类及其作用,并对组蛋白去乙酰化酶抑制剂在神经变性疾病中治疗作用的可能机制,如神经细胞的保护作用、促进神经营养因子的释放以及与疾病相关蛋白调节作用等方面进行综述。
Histone acetylation plays a key role in gene transcription and expression and is associated with the pathological processes of a variety of neurodegenerative diseases. Therefore, histone deacetylase inhibitors have become the research hotspots in recent years. This article summarizes the histone deacetylase inhibitor classifications and their roles and their possible mechanisms for the treatment of histone deacetylase inhibitors in neurodegenerative diseases such as neuronal protection and neurotrophic factor release As well as the disease-related protein regulation and so on.