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为了解肝硬化 (LC)患者血清胰岛素样生长因子 (IGF - 1)、视黄醇结合蛋白 (RBP)水平变化及其与患者肝功能损伤的关系 ,用ELISA法和比浊法检测了 5 0例LC患者和 2 0例正常人的血清IGF - 1和RBP水平。LC患者血清IGF - 1和RBP水平均显著低于对照组 (P均 <0 0 1) ,且在肝功能分级中 ,随childA、B、C级的升高而递减 ,各组间比较差异有极显著意义 (P <0 0 5 )。表明 :IGF - 1和RBP是反映肝实质损害的灵敏指标 ,可较好反映肝硬化病情的严重程度
In order to understand the relationship between serum insulin - like growth factor (IGF - 1), retinol binding protein (RBP) levels and hepatic injury in patients with cirrhosis (LC), ELISA and turbidimetry were used to detect 50 Serum IGF - 1 and RBP levels were measured in patients with LC and 20 normal controls. The levels of serum IGF - 1 and RBP in LC patients were significantly lower than those in control group (all P <0 01), and decreased with the increase of childA, B and C levels in liver function classification Extremely significant (P <0 05). The results showed that IGF - 1 and RBP were sensitive indicators of liver parenchymal damage, which could reflect the severity of cirrhosis