目的探讨系统性淋巴结清扫术治疗子宫内膜癌的临床疗效及对性激素水平的影响。方法选取2013年10月至2015年3月间收治的120例子宫内膜癌患者,依据手术范围的不同分为实验组和对照组,每组60例。实验组患者接受次广泛子宫全切+双附件切除+盆腔淋巴结清扫术+腹主动脉旁淋巴结清扫术,对照组患者接受次广泛子宫全切+双附件切除+盆腔淋巴结清扫术。比较两组患者下肢水肿、深静脉血栓、不全性肠梗阻发生率以及雌激素和孕激素水平。结果与对照组比较,实验组患者3年、5年生存率升高,复发率降低,差异有统计学意义(P<0.05)。与对照组患者相比较,实验组患者下肢水肿、深静脉血栓、不全性肠梗阻发生率均明显降低,差异有统计学意义(P<0.05)。与对照组比较,实验组患者术前雌激素和孕激素水平间差异无统计学意义(t=1.24,P>0.05;t=1.36,P>0.05);实验组患者术后3个月雌激素水平降低,孕激素水平升高,差异有统计学意义(t=3.56,P<0.05;t=3.11,P<0.05)。与术前相比,术后3个月对照组患者雌激素水平降低,孕激素水平升高,差异有统计学意义(t=3.03,P<0.05;t=2.58,P<0.05)。两组术后雌激素和孕激素水平间差异有统计学意义(t=3.25,P<0.05;t=3.15,P<0.05)。与对照组比较,实验组患者淋巴结清扫数增多、出血量减少、手术时间延长,组间差异有统计学意义(P<0.05)。结论采用系统性淋巴结清扫术治疗子宫内膜癌的临床疗效突出,可改善患者雌激素水平,较传统局部淋巴结清扫手术具有诸多优势,可作为一种理想方法应用于临床工作中。 Objective To investigate the clinical efficacy of systemic lymphadenectomy in the treatment of endometrial carcinoma and its effects on sex hormone levels. Methods A total of 120 patients with endometrial cancer who were admitted between October 2013 and March 2015 were divided into experimental group and control group according to the scope of the operation, with 60 cases in each group. The patients in the experimental group underwent extensive uterine dissection + double attachment resection + pelvic lymphadenectomy + para-aortic lymph node dissection, and patients in the control group underwent extensive uterine radical resection + double-attachment excision + pelvic lymphadenectomy. Lower extremity edema, deep venous thrombosis, the incidence of incomplete intestinal obstruction and estrogen and progesterone levels were compared between the two groups. Results Compared with the control group, the 3-year, 5-year survival rate and the recurrence rate of the experimental group were significantly decreased (P <0.05). Compared with the control group, the incidence of lower extremity edema, deep vein thrombosis and incomplete intestinal obstruction in the experimental group were significantly decreased (P <0.05). Compared with the control group, there was no significant difference in preoperative estrogen and progesterone levels between the experimental group and the control group (t = 1.24, P> 0.05; t = 1.36, P> 0.05) (T = 3.56, P <0.05; t = 3.11, P <0.05), and the level of progesterone increased. The levels of estrogen and progesterone in the control group were significantly lower than those in the preoperative 3 months after operation (t = 3.03, P <0.05; t = 2.58, P <0.05). The postoperative estrogen and progestin levels were significantly different between the two groups (t = 3.25, P <0.05; t = 3.15, P <0.05). Compared with the control group, the number of lymph node dissection in the experimental group increased, the amount of bleeding decreased, the operation time was prolonged, the difference between the two groups was statistically significant (P <0.05). Conclusion The clinical efficacy of systemic lymphadenectomy for the treatment of endometrial cancer is outstanding, which can improve the level of estrogen in patients. Compared with traditional local lymph node dissection, it has many advantages and can be used as an ideal method in clinical work.