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目的评价左旋氧氟沙星与克拉霉素治疗幽门螺旋杆菌(Hp)阳性消化性溃疡(胃/十二指肠溃疡)的成本-效果和不良反应分析。方法将80例幽门螺杆菌阳性消化性溃疡患者随机分成2组,实验组40例:口服左旋氧氟沙星0.2,阿莫西林1.0,泮托拉唑40mg,各2次/d;对照组40例:口服克拉霉素0.5,阿莫西林1.0,泮托拉唑40mg,各2次/d,两组疗程均为10d。观察两组治疗方案的疗效、不良反应并运用药物经济学成本-效果分析法进行评价。结果实验组Hp根除率为97.5%,高于对照组92.5%,但差异无统计学意义(P>0.05);两组在溃疡愈合率及不良反应发生率方面差异亦无统计学意义(P>0.05),但成本-效果方面比较差异有统计学意义(P<0.01)。结论左旋氧氟沙星与克拉霉素均能有效治疗Hp阳性消化性溃疡,左旋氧氟沙星成本-效果优于克拉霉素,在不良反应方面差异无统计学意义。
Objective To evaluate the cost-effectiveness and adverse reactions of levofloxacin and clarithromycin in the treatment of H.pylori-positive peptic ulcer (gastric / duodenal ulcer). Methods Eighty patients with Helicobacter pylori-positive peptic ulcer were randomly divided into two groups. The experimental group consisted of 40 patients: oral levofloxacin 0.2, amoxicillin 1.0, pantoprazole 40 mg twice daily and control group 40 Example: Oral clarithromycin 0.5, amoxicillin 1.0, pantoprazole 40mg, 2 times / d, two courses of treatment were 10d. The curative effects and adverse reactions of the two groups were observed and evaluated by cost-effectiveness analysis. Results The eradication rate of Hp in the experimental group was 97.5%, which was higher than that in the control group (92.5%), but the difference was not statistically significant (P> 0.05). There was no significant difference between the two groups in the healing rate of ulcer and the incidence of adverse reactions (P> 0.05), but the difference in cost-effectiveness was statistically significant (P <0.01). Conclusions Both levofloxacin and clarithromycin can effectively treat Hp positive peptic ulcer. The cost-effectiveness of levofloxacin is superior to that of clarithromycin, and there is no significant difference in adverse reactions.