蛋白酶激活受体PARs是一种G蛋白偶联受体超家族,介导跨膜信号转导并调节细胞功能。其共有4个成员,可由凝血酶和类胰蛋白酶这两种丝氨酸蛋白酶类分别激活PAR1、PAR3、PAR4和PAR2,激活后参与许多疾病的发生和发展过程,其中在炎症性肠病(inflammatory bowel disease,IBD)的发病中 Protease-activated receptors PARs are a family of G-protein coupled receptors that mediate transmembrane signaling and regulate cellular functions. It consists of 4 members, which can activate PAR1, PAR3, PAR4 and PAR2 respectively by two serine proteases such as thrombin and tryptase. After activation, PAR1, PAR3 and PAR2 are involved in the occurrence and development of many diseases. Among them, inflammatory bowel disease , IBD) in the pathogenesis