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根据性别和感染途径不同,研究分析55例原发性HIV感染者/AIDS病人外周血T淋巴细胞亚群、血浆病毒载量和IL-2、sIL-2R、IL-6、IL-10、TNF-α、sTNFR-I、Neopterin浓度。结果发现,HIV感染者中,女性患者CD3、CD4、CD8细胞高于男性,血浆病毒载量和IL-2、sIL-2R、IL-6、IL-10、TNF-α、sTNFR-I、Neopterin则低于男性,但彼此间均无显著性差异;而在AIDS病人中,女性患者CD4细胞（24/mm3）明显低于男性AIDS病人（135/mm3,P<0.001）和女性HIV感染者（381/mm3,P<0.001）,血浆病毒载量和sIL-2R、TNF-α、sTNFR-I、Neopterin浓度高于男性病人,且与女性HIV感染者比较均有显著性差异。经性途径感染者（S组）的CD3、CD4、CD8细胞和血浆IL-10浓度经静脉吸毒（I组）和血液途径（B组）感染者,且CD4细胞数各组间有明显差异（P<0.001和 P<0.05）,血浆病毒载量和 sTNFR-I、Neopterin浓度有显著性差异。提示女性HIV感染者可能较男性及经性和吸毒途径感染者较血液途径感染者容易发展成为AIDS,因此在选择进行抗病毒治疗时间时应考虑性别和感染途径的差异及其对病程发展的影响。
According to the difference of sex and route of infection, the levels of T lymphocyte subsets, plasma viral load and IL-2, sIL-2R, IL-6, IL-10 and TNF in peripheral blood of 55 patients with primary HIV / -α, sTNFR-I, Neopterin concentration. The results showed that among HIV-infected women, the levels of CD3, CD4 and CD8 in female patients were higher than those in men, and the plasma viral load and IL-2, sIL-2R, IL-6, IL-10, TNF-α, sTNFR- (24 / mm3) was significantly lower in female patients than in male AIDS patients (135 / mm3, P <0.001) and in female HIV-infected patients ( 381 / mm3, P <0.001). The plasma viral load and the concentrations of sIL-2R, TNF-α, sTNFR-I and Neopterin were higher than those of male patients, which were significantly different from those of HIV-infected women. The CD3, CD4, CD8 cells and plasma IL-10 levels of patients infected by sexual route (group S) were infected by intravenous drug use (group I) and blood route (group B), and there were significant differences between the groups P <0.001 and P <0.05). There was a significant difference in plasma viral load and sTNFR-I and Neopterin concentrations. Suggesting that women living with HIV may be more likely than men and those who are sexually and drug-infected to develop AIDS more easily than those who are infected by the bloodstream. Therefore, gender and route of infection should be considered when choosing antiviral therapy and its impact on disease progression .