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[目的]观察瘅痛酊与辣椒碱软膏分别联合西药治疗糖尿病周围神经病变疗效。[方法]使用随机平行对照方法,将120例住院患者按随机数字表法分为三组。常规组(C组)40例控制饮食、适当运动、糖尿病教育、心理调节及口服降血糖药物或者皮下注射胰岛素使空腹血糖控制于<8.0mmol/L,餐后血糖控制于8~10mmol/L。0.4g血塞通+0.9%生理盐水100mL,1次/d,静滴。1mL甲钴胺+30mL的0.9%生理盐水,1次/d,静注。瘅痛酊组(A组)40例瘅痛酊,外擦患处(剂量视病变部位及范围而定),2次/d。西药治疗同常规组。辣椒碱组(B组)40例辣椒碱软膏外擦患处(剂量视病变部位及范围而定),2次/d。西药治疗同常规组。治疗20d为1疗程。观测临床症状、TCSS总积分、神经传导速度、不良反应。连续治疗1疗程(20d),判定疗效。[结果]瘅痛酊组基本缓解5例,显效12例,有效19例,无效4例,总有效率90.00%。辣椒碱组基本缓解3例,显效9例,有效23例,无效5例,总有效率87.50%。常规组基本缓解2例,显效4例,有效26例,无效8例,总有效率80.00%。临床疗效A组改善优于B、C组(P<0.05)。神经传导速度三组均有改善(P<0.05),A组改善优于B、C组(P<0.05)。TCSS总积分方差分析三组均有改善(P<0.05),A组改善优于B、C组(P<0.05)。[结论]瘅痛酊与辣椒碱软膏分别联合西药治疗糖尿病周围神经病变效果显著,值得推广。
[Objective] To observe the curative effect of Tonghu tincture and capsaicin ointment respectively combined with Western medicine on diabetic peripheral neuropathy. [Methods] Using randomized parallel method, 120 inpatients were divided into three groups according to random number table. Control group diet, exercise, diabetes education, psychological adjustment and oral hypoglycemic drugs or subcutaneous insulin in control group (C group) controlled the fasting blood glucose to <8.0mmol / L and postprandial blood glucose to 8 ~ 10mmol / L. 0.4g Xuesaitong + 0.9% saline 100mL, 1 / d, intravenous infusion. 1mL methylcobalamin + 30mL 0.9% saline, 1 times / d, intravenous injection. Forty Tong tincture group (A group) 40 cases of painful tincture, rubbing the affected area (dose depending on the location and extent of the lesion), 2 times / d. Western medicine treatment with the conventional group. Capsaicin group (B group) 40 cases of capsaicin ointment rubbing the affected area (dose depending on the lesion site and scope), 2 times / d. Western medicine treatment with the conventional group. Treatment of 20d for a course of treatment. Observed clinical symptoms, TCSS total score, nerve conduction velocity, adverse reactions. Continuous treatment of a course of treatment (20d), determine the efficacy. [Result] In Tongreng tincture group, 5 cases were basically relieved, 12 cases were markedly effective, 19 cases were effective, 4 cases were ineffective and the total effective rate was 90.00%. In the capsaicin group, 3 cases were relieved, 9 cases were markedly effective, 23 cases were effective, 5 cases were ineffective, and the total effective rate was 87.50%. The conventional group basically relieved in 2 cases, markedly effective in 4 cases, effective in 26 cases, ineffective in 8 cases, the total effective rate was 80.00%. The clinical efficacy of group A was better than group B and C (P <0.05). The nerve conduction velocity was improved in all three groups (P <0.05). The improvement in group A was better than that in group B and C (P <0.05). TCSS total score analysis of variance improved in all three groups (P <0.05), A group improved better than B, C group (P <0.05). [Conclusion] Tonghu tincture and capsaicin ointment, respectively, combined with Western medicine treatment of diabetic peripheral neuropathy significant effect, it is worth promoting.