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为了探讨胰岛淀粉样多肽（ＩＡＰＰ）在人胎阑尾中的个体发生及其与其他生物活性物质的关系，用免疫组织化学ＰＡＰ法，对３６例１２～３８周人胎阑尾中ＩＡＰＰ免疫反应性（ＩＲ）细胞、生长抑素（ＳＳ）－ＩＲ细胞和５－羟色胺（５－ＨＴ）－ＩＲ细胞进行定位研究。结果表明，胎１２周，阑尾上皮中已可见到ＳＳ－ＩＲ细胞，而ＩＡＰＰ－及５－ＨＴ－ＩＲ细胞于１４周才见到。在整个胎期，阑尾中的ＩＡＰＰ－及ＳＳ－ＩＲ细胞始终分散存在，数量较少；而５－ＨＴ－ＩＲ细胞数量随胎龄增长而发生变化，胎１５～２１周为高峰期。经邻片比较观察，未见到ＩＡＰＰ与ＳＳ或５－ＨＴ在同一细胞有共存现象。本研究表明，胎期阑尾的内分泌细胞已可合成ＩＡＰＰ、ＳＳ及５－ＨＴ。
In order to investigate the occurrence of islet amyloid polypeptide (IAPP) in the appendix of the human fetus and its relationship with other biologically active substances, immunohistochemical PAP method was used to detect IAPP immunoreactivity IR) cells, somatostatin (SS) -IR cells and serotonin (5-HT) -IR cells. The results showed that SS-IR cells were found in the appendix epithelium in 12 weeks, while IAPP- and 5-HT-IR cells were only seen in 14 weeks. The number of IAPP- and SS-IR cells in the appendix remained dispersed throughout the entire life span, with fewer numbers. The number of 5-HT-IR cells varied with gestational age and peaked at 15-21 weeks. By comparing the neighboring tablets, IAPP did not see the coexistence of IAPP with SS or 5-HT in the same cell. This study shows that endocrine cells of the appendix of the fetal stage can synthesize IAPP, SS and 5-HT.