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选7月龄时接种过3针白喉-百日咳-破伤风菌苗-脊髓灰质炎灭活疫苗/磷酸聚核糖基核糖醇（PRP）-破伤风蛋白联合疫苗（PENTA~（TM）疫苗）的婴,于12月龄时再接种1针麻疹-腮腺炎-风疹疫苗（MMR）,并随机分为3组,分别于12月龄（86人与 MMR疫苗同时）、15月龄（85人）和18月龄（82人）时再加强接种1针PENTA~（TM）疫苗。观察不同月龄婴儿加强免疫后的局部和全身反应以及免疫应答情况。
A 3-dose, diphtheria-pertussis-tetanus vaccine-poliomyelitis inactivated vaccine / polyphosphatemylphosphate (PRP) -pneumonic conjugate vaccine (PENTA ™ vaccine) was vaccinated at 7 months of age (MMR) at 12 months of age and were randomly divided into three groups at 12 months of age (86 simultaneous with MMR vaccine), 15 months of age (85) and 18-month-old (82) and then strengthen the vaccination 1-pin PENTA TM vaccine. To observe the different month-old baby to enhance local and systemic immune response and immune response.