论文部分内容阅读
目的 :研究酸味中药复方对糖尿病大鼠动脉硬化的作用。方法 :采用免疫组织化学法、图像分析法观察了该方对链脲佐菌素(STZ)诱导的糖尿病大鼠血糖和腹主动脉终末糖化产物(AGES)、腹主动脉α SM 肌动蛋白、血小板源生长因子 A(PDGF A)及血管平滑肌细胞(VSMC)的影响。结果 :酸味中药复方有降低血糖、减少AGES 含量、降低PDGF A水平、提高α SM 肌动蛋白水平以及抑制VSMC增生的作用。结论 :酸味中药复方对糖尿病大鼠的动脉硬化有一定的防治作用。
Objective : To study the effect of sour herb compound on atherosclerosis in diabetic rats. METHODS: Immunohistochemistry and image analysis were used to observe the effects of STZ-induced diabetic rats on blood glucose and abdominal aortic glycosylation products (AGES) and abdominal aorta α SM actin. Effects of platelet-derived growth factor A (PDGF A) and vascular smooth muscle cells (VSMC). RESULTS: The Chinese herbal compound with sour taste had the effects of lowering blood glucose, reducing AGES content, decreasing PDGF A level, increasing α SM actin level, and inhibiting proliferation of VSMC. Conclusion : Sour Chinese herbal compound has certain preventive and therapeutic effects on arteriosclerosis in diabetic rats.