目的探讨消化道类癌发生部位与组织学分型、细胞核DNA含量的关系。方法对78例类癌按照GOULD方法进行组织学分型:典型类癌33例,非典型类癌26例,低分化类癌19例。分析其发生部位与组织学分型的关系,同时行细胞核DNA定量。结果78例类癌只有2例发生于阑尾,典型类癌绝大部分分布于后肠(30/33),低分化类癌大部分分布于前肠(14/19)。前肠发生的类癌绝大多数为异倍体(19/21),后肠类癌倍体分布较为均匀,二倍体稍占优势(18/32)。典型类癌多为二倍体(19/27),非典型类癌与低分化类癌多为异倍体(17/22,11/12),且后者多为非整倍体。值得注意的是:尽管典型类癌绝大多数分布与后肠,但仍有相当比例属异倍体(8/27)。结论类癌首发部位为后肠,阑尾是否为消化道类癌首发部位,值得商榷。发生于后肠的典型类癌,当DNA检测为二倍体时,可被视为良性;当DNA检测为异倍体时,应当被视为恶性或低度恶性,类癌发生部位、组织学分型、DNA定量分析、有助于类癌的良恶性判断及预后的估计。 Objective To investigate the relationship between the carcinogenesis site and histological type and nuclear DNA content in gastrointestinal carcinoid. Methods Totally 78 cases of carcinoid tumor were classified according to the GOULD method: 33 cases of typical carcinoid, 26 cases of atypical carcinoid and 19 cases of poorly differentiated carcinoid. Analysis of the relationship between the site of occurrence and histological classification, while quantitative nuclear DNA. Results Only 78 cases of carcinoid carcinoid occurred in the appendix. The majority of typical carcinoids were found in the hindgut (30/33). The majority of poorly differentiated carcinomas were found in the foregut (14/19). The vast majority of carcinoid tumors in the foregut were aneuploid (19/21), and the hindgut carcinoid was more evenly distributed and the diploid slightly predominant (18/32). Typical carcinoid mostly diploid (19/27), atypical carcinoid and poorly differentiated carcinoid mostly aneuploid (17 / 22,11 / 12), and the latter mostly aneuploidy. It is worth noting that although the majority of typical carcinoid tumors are distributed in the hindgut, a considerable proportion of aneuploidy (8/27) remains. Conclusions The primary site of carcinoid tumor is the hindgut, the appendix is ​​the first part of gastrointestinal carcinoid, is debatable. Typical carcinoids that occur in the hindgut can be considered benign when the DNA is detected as diploid and should be considered as malignant or less malignant when the DNA is detected as aneuploidy, Type, DNA quantitative analysis, contribute to carcinoid benign and malignant judgment and prognosis.