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[目的]探讨糖耐量正常的肥胖女性糖负荷1小时血糖(1hPG)与颈动脉内膜中层厚度(CIMT)的相关性.[方法]选取2014年5～12月在河北省秦皇岛市第一医院体检中心进行体检的186例女性,按体质量指数(BMI)将其分为正常组、超重组和肥胖组.所有研究对象行口服葡萄糖耐量试验,并测定CIMT.比较三组不同时间点血糖、胰岛素(INS)水平,分析CIMT的相关影响因素.[结果]肥胖组收缩压(SBP)、三酰甘油(TG)、CLMT高于正常组,肥胖组胰岛素抵抗指数(HOMA-IR)高于超重组,差异均具有统计学意义(均P＜0.05).肥胖组血清1 hPG、0hINS、1hINS水平显著高于正常组,0hINS、1hINS水平显著高于超重组,差异均具有统计学意义(均P＜0.05).CIMT与BMI(r=0.316,P=0.001)、FPG(r =0.328,P＜0.001)、1hPG(r =0.263,p=0.005)均具有相关性(P＜0.05).多元线性回归显示,1hPG、年龄、BMI与CIMT呈显著正相关(P＜0.05).[结论]糖耐量正常的肥胖女性已存在1hPG、1hINS升高及胰岛素抵抗,1hPG是CIMT的独立危险因素.“,”[Objective]To explore the relationship between 1h post-load plasma glucose (1hPG) elevation and carotid intima-media thickness (CIMT) in obese women with normal glucose tolerance (NGT).[Methods]A total of 186 women who underwent physical examination in our hospital (May to December,2014) were collected for the study.They were 18-57 years old with NGT.According to the body mass index (BMI),all cases were divided into normal (n =82),overweight (n =63) and obese (n =41) groups.All subjects underwent an oral glucose tolerance test (OGTT) and CIMT.The levels of blood glucose and insulin (INS) were compared among the three groups.Furthermore,the correlation between 1hPG and CIMT was analyzed.[Results] Systolic blood pressure (SBP),triglyceride (TG) and CIMT in the obese group were higher than those in the normal group (P ＜0.05).Insulin resistance index (HOMA-1R) in the obese group was _higher than that in the overweight group (P ＜0.05).Serum 1hPG,0hINS and 1hINS levels in the obese group were significantly higher than those in the normal group,and serum 0hINS and 1hINS levels were significantly higher than those in the overweight group.All differences were statistically significant (P ＜ 0.05).Other parameters (0.5hPG,1 hPG,2hPG,3hPG,0.5hINS,2hINS and 3hINS) in the three groups were not statistically significant.CIMT was correlated with BMI (r =0.316,P =0.001),fasting plasma glucose (FPG) (r =0.328,P ＜0.328),and 1hPG (r =0.263,P =0.005),(all P ＜0.05).Multiple linear regression showed that 1hPG,age and BMI had a significant positive correlation with CIMT (P ＜0.05).[Conclusion] Obese women with normal glucose tolerance have 1hPG,1hINS and insulin resistance.1hPG is an independent risk factor for carotid intima-media thickening (CIMT).