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实验在47只静脉麻醉、肌肉麻痹的家兔上进行。观察到侧脑室注射(icv)SP 20μg引起心输出量、血压明显升高;预先icv心得安100μg或阿托品150μg处理,SP增加心输出量和升压效应仍然存在。提示SP在脑内具有增强心血管活动作用,在其兴奋心血管活动中没有中枢递质乙酰胆碱(Ach)或去甲肾上腺素(NE)的参与。此外,为了解SP与Ach在调节心血管活动的相互关系,本实验还观察到icv毒扁豆碱(PHY)60μg引起心输出量、血压升高;预先icvSP阻断剂25μg可阻断PHY的上述效应,提示Ach调节心血管活动是通过脑内SP起作用的。
Experiments were performed on 47 venous anesthetized and muscle-paralyzed rabbits. Observed intraventricular injection (icv) SP 20μg caused cardiac output, blood pressure was significantly increased; pre-icv propranolol 100μg or atropine 150μg treatment, SP increased cardiac output and the effect of increasing pressure still exists. Tip SP in the brain has the role of cardiovascular activity, in its excitement of cardiovascular activity in the absence of central transmitter acetylcholine (Ach) or norepinephrine (NE) participation. In addition, in order to understand the relationship between SP and Ach in the regulation of cardiovascular activity, we also observed that 60 μg icv physostigmine (PHY) resulted in cardiac output and elevated blood pressure. Pre-icvSP blockers 25 μg blocked the above Effect, suggesting that Ach regulates cardiovascular activity through the brain SP.