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目的：了解粘附分子与抑制肿瘤转移基因ｎｍ２３·Ｈ１在急性髓系白血病（ＡＭＬ）细胞上表达的临床意义。方法：用间接免疫荧光染色，流式细胞术分析６８例初治ＡＭＬ治疗前后ＣＤ４４和ｎｍ２３·Ｈ１的表达。结果：６８例中ＣＤ＋４４／ｎｍ２３·Ｈ＋１３０例中有１４例肝脾肿大，１０例脾肿大，２例淋巴结肿大，１０例中枢神经系统白血病，４例牙龈增生，６例骨痛；ＣＤ－４４／ｎｍ２３·Ｈ＋１１６例中６例肝脾肿大，２例肝、脾、淋巴结肿大；ＣＤ－４４／ｎｍ２３·Ｈ－１２２例无髓外浸润表现。ＣＤ＋４４／ｎｍ２３·Ｈ＋１者完全缓解率为８６．７％，ＣＤ－４４／ｎｍ２３·Ｈ＋１者为７５．０％，ＣＤ－４４／ｎｍ２３·Ｈ－１者则为８１．８％。６例完全缓解后ＣＤ＋４４／ｎｍ２３·Ｈ＋１者早期髓外复发。结论：ＣＤ４４和ｎｍ２３·Ｈ１表达对ＡＭＬ的治疗效果无影响，表达阳性者易有髓外浸润和早期髓外复发。
Objective: To investigate the clinical significance of adhesion molecule and inhibition of tumor metastasis gene nm23·H1 expression in acute myeloid leukemia (AML) cells. Methods: The expressions of CD44 and nm23·H1 in 68 patients with newly treated AML before and after treatment were analyzed by indirect immunofluorescence staining and flow cytometry. RESULTS: Of the 68 patients with CD+44/nm23·H+130, there were 14 cases of hepatosplenomegaly, 10 cases of splenomegaly, 2 cases of lymphadenopathy, 10 cases of central nervous system leukemia, 4 cases of gingival hyperplasia, and 6 cases of bone pain; CD Among the cases with -44/nm23·H+116, 6 cases had hepatosplenomegaly, 2 cases had liver, spleen, and lymph node enlargement; CD-44/nm23·H-122 cases showed no extramedullary infiltration. The complete remission rate was 86.7% in CD+44/nm23·H+1, 75.0% in CD-44/nm23·H+1, and 81.8% in CD-44/nm23·H-1. 6 cases of complete remission after CD+44/nm23·H+1 early extramedullary recurrence. Conclusion: The expression of CD44 and nm23·H1 has no effect on the therapeutic effect of AML. The positive expression of CD44 and nm23·H1 is easy to have extramedullary infiltration and early extramedullary recurrence.