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在建立稳定的大臣脑出血模型的基础上,用放免法测定不同脑区和垂体中DynA1-13含量,干湿重法测定含水量,旨在观察DynA1-13对脑出血后脑组织合水量的影响。结果发现:大鼠尾核注射胶原酶,可造成稳定的脑实质出血;注射胶原酶后4,24,48h脑组织含水量均明显升高(P<0.01);在脑出血后4,24,48h,Dy-nA1-13含量,在皮质、海马与尾壳核均明显降低(P<0.05,P<0.01),而在下丘脑及垂体则明显升高(P<0.05,P<0.01);DynA1-13可减轻胶原酶诱导的脑出血后脑水肿(P<0.01),并呈剂量依赖效应。本研究提示:脑组织DynA1-13含量降低,可能是造成脑出血后脑水肿的一个重要原因,DynA1-13对脑出血后脑水肿具有潜在的治疗价值。
On the basis of establishing a stable miniscule cerebral hemorrhage model, the content of DynA1-13 in different brain regions and pituitary gland was determined by radioimmunoassay and the content of DynA1-13 in brain tissue after cerebral hemorrhage . The results showed that the injection of collagenase into the caudate nucleus of rats resulted in stable cerebral parenchymal hemorrhage. After 4, 24 and 48 hours of injection of collagenase, the water content of brain tissue were significantly increased (P <0.01) The content of Dy-nA1-13 in 24 h, 48 h, and 48 h in the hippocampus and caudate putamen were significantly decreased (P <0.05, P <0.01), but significantly higher in the hypothalamus and pituitary (P <0. 05, P <0.01). DynA1-13 could relieve cerebral edema induced by collagenase (P <0.01) induced by collagenase in a dose-dependent manner. This study suggests that the decrease of DynA1-13 in brain tissue may be one of the most important causes of cerebral edema after intracerebral hemorrhage. DynA1-13 has potential therapeutic value in cerebral edema after intracerebral hemorrhage.