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３２例ＮＩＤＤＭ患者，分血小板聚集功能亢进组（ｎ＝１７）和无亢进组（ｎ＝１５），探讨Ｃａ２＋转运影响血小板胞浆游离Ｃａ２＋（［Ｃａ２＋］ｉ）变化与最大聚集（ＭＡＲ）的关系。结果：亢进组血小板静息［Ｃａ２＋］ｉ高于对照组（１３４．４±２６．４对１０１．５±１３．３ｎｍｏｌ／Ｌ，Ｐ＜０．０１）。［Ｃａ２＋］ｉ与ＭＡＲ呈正相关（ｒ＝０．３２１９，Ｐ＜０．０５）以凝血酶刺激，有胞外Ｃａ２＋内流及胞内Ｃａ２＋释放时，亢进组［Ｃａ２＋］ｉ高于对照组（９１８．９±２０７．６对７９１．２±１１９．６ｎｍｏｌ／Ｌ，Ｐ＜０．０１），并与ＭＡＲ呈正相关（ｒ＝０．３３７１，Ｐ＜０．０１）；以ＴＭＢ８阻滞胞内Ｃａ２＋释放，组间差异仍然显著（Ｐ＜０．０５）；当缺乏胞外Ｃａ２＋内流时，则组间不呈显著差异（Ｐ＞０．０５）。以钙载体Ａ２３１８７刺激，在有或无胞外Ｃａ２＋时，亢进组［Ｃａ２＋］ｉ均高于对照组（Ｐ均＜０．０５）然而，无亢进组上述各指标与对照组间均未呈显著差异。提示ＮＩＤＤＭ患者血小板聚集功能亢进与［Ｃａ２＋］ｉ变化有关，可能涉及胞浆内Ｃａ２＋稳态异常，凝血酶刺激胞外Ｃａ２＋内流及Ａ２３１８７作用胞内Ｃａ２＋释放增强等环节
Thirty-two patients with NIDDM were divided into two groups according to platelet hyperfunction group (n = 17) and non-hypertensive group (n = 15). The relationship between the change of Ca2 + transporter platelet Ca2 + . Results: The platelet resting [Ca2 +] i in hyperthyroidism group was higher than that in control group (134.4 ± 26.4 vs. 101.5 ± 13.3 nmol / L, P <0.01). [Ca2 +] i was positively correlated with MAR (r = 0.3219, P <0.05), and was increased by thrombin. When extracellular Ca2 + influx and intracellular Ca2 + release, [Ca2 +] i in hyperthyroidism group was higher than that in control group 918.9 ± 207.6 vs. 791.2 ± 119.6 nmol / L, P <0.01), and positively correlated with MAR (r = 0.3371, P <0.01) Ca2 + release, the difference between groups was still significant (P <0.05). When there was no extracellular Ca2 + influx, there was no significant difference between the two groups (P> 0.05). Ca2 +] i in hyperthyroidism group was significantly higher than that in control group (P <0.05), but there was no significant difference between hyperthyroidism group and control group difference. These results suggest that platelet aggregation in patients with NIDDM may be related to the change of [Ca2 +] i, which may involve the abnormality of intracellular Ca2 + homeostasis, the influx of extracellular Ca2 + by thrombin and the enhancement of intracellular Ca2 + release by A23187