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一向认为TSH分泌过多为甲状腺机能亢进症(以下简称甲亢)的起因,然而下列现象否定了TSH为甲亢病因的学说:①甲亢可在垂体腺瘤或产后引起的垂体功能减退,甚至在切除垂体后发生,②在尸检中垂体分泌TSH细胞不亢进,多数呈抑制,③早期用生物测定法测定甲亢病人TSH水平显示其分泌并不增多。最近用较敏感的放射免疫法测定显示多数病人血中TSH水平编低,甚至不能测得。 Adams等用甲状腺素抑制了豚鼠TSH的分泌后,测定甲状腺I~(131)吸收率,然后静脉注射TSH,发现作用高峰在注射后3小时出现。若用甲亢病人的血清注射,则9例中有5例在
TSH secretion has always been considered as the cause of hyperthyroidism (hereinafter referred to as hyperthyroidism), but the following phenomenon denied the TSH as the cause of hyperthyroidism theory: ① hyperthyroidism in pituitary adenomas or postpartum caused by hypopituitarism, even in the removal of pituitary After the occurrence, ② TSH cells in the autopsy pituitary secretion is not hyperthyroidism, most were inhibited, ③ early bioassay to determine the level of TSH in patients with hyperthyroidism showed no increase in their secretion. Recently, the more sensitive radioimmunoassay showed that most patients’ TSH levels in blood were low or even undetectable. Adams and other thyroxine inhibited the secretion of guinea pig TSH, the determination of thyroid I ~ (131) absorption rate, and then intravenous injection of TSH, the peak was found 3 hours after injection. If hyperthyroidism patients with serum injection, then 9 cases in 5 cases