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目的 探讨肺炎链球菌在儿童急性下呼吸道感染 (ALRI)中的地位 ,并比较多种抗体检测方法在诊断肺炎链球菌感染中的作用。方法 通过配对血清及循环免疫复合物使用EIA方法对 10 1例ALRI患儿进行肺炎链球菌抗体检测。结果 10 1例ALRI患儿中 ,肺炎链球菌感染 17例 (16 8% ) ,其中从血清中检测抗体 ,9例(8 9% )阳性 ,从循环免疫复合物中检测抗体 12例 (11 9% )阳性。结论 肺炎链球菌是儿童ALRI的常见病原。从循环免疫复合物中检测肺炎链球菌抗体的敏感性优于从血清检测抗体 ,由于两者存在无重叠部分 ,应联合使用 ,互相补充
Objective To investigate the status of Streptococcus pneumoniae in children with acute lower respiratory tract infection (ALRI) and compare the diagnostic value of various antibodies in the diagnosis of Streptococcus pneumoniae infection. Methods EIA was performed on paired sera and circulating immune complexes to detect the S. pneumoniae antibody in 101 children with ALRI. Results Of the 11 cases of ALRI, 17 (16.8%) were infected with S. pneumoniae, of which 9 (89%) were positive for serum antibody detection and 12 were for antibody detection from circulating immune complex %) Positive. Conclusion Streptococcus pneumoniae is a common ALRI in children. The detection of antibodies against S. pneumoniae from circulating immune complexes is superior to the detection of antibodies from serum, since there is no overlap between the two, should be used in combination to complement each other