论文部分内容阅读
目的观察缬沙坦联合应用胺碘酮治疗阵发性房颤的疗效。方法 130例阵发性房颤患者随机分为治疗组和对照组各65例,对照组给予胺碘酮口服,治疗组给予胺碘酮和缬沙坦口服。比较两组治疗后3、6、12个月的窦性心律维持率和治疗前后左心房内径。结果治疗后第3、6个月,治疗组窦性心律的维持率分别是88.3%和81.5%,对照组分别为84.2%和73.5%,两组比较,无统计学差异(P>0.05);治疗后第12个月,治疗组窦性心律维持率为79.0%,对照组为58.5%,两组差异有统计学意义(P<0.05);两组左房内径比较,差异有统计学意义(P<0.05)。结论胺碘酮联合应用缬沙坦治疗阵发性房颤疗效确切,可有效控制左房扩大,值得临床应用。
Objective To observe the efficacy of valsartan combined with amiodarone in the treatment of paroxysmal atrial fibrillation. Methods 130 patients with paroxysmal atrial fibrillation were randomly divided into treatment group and control group, 65 cases in each group. The control group was given amiodarone orally. The treatment group was given amiodarone and valsartan orally. The maintenance rate of sinus rhythm at 3, 6, and 12 months after treatment was compared between two groups before and after treatment. Results The maintenance rates of sinus rhythm in the treatment group were 88.3% and 81.5% at 3 and 6 months after treatment, respectively, 84.2% and 73.5% in the control group, respectively. There was no significant difference between the two groups (P> 0.05). In the 12th month after treatment, the maintenance rate of sinus rhythm in the treatment group was 79.0% and in the control group was 58.5%, there was significant difference between the two groups (P <0.05). There was significant difference in the left atrial diameter between the two groups P <0.05). Conclusion Amiodarone combined with valsartan in the treatment of paroxysmal atrial fibrillation curative effect is exact, can effectively control the left atrial enlargement, is worth clinical application.