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对72例尘肺及19名健康志愿者的支气管肺泡灌洗液(BALF)进行了细胞学及生化成份的分析。结果提示矽肺早期阶段(Ⅰ期)细胞浓度明显高于正常对照组及其他各期矽肺;细胞分类表现为矽肺淋巴细胞(Lym)比率增加,石棉肺除Lym增加外,嗜中性细胞(Neut)亦明显增加;矽肺、石棉肺的肺泡巨噬细胞(PAM)比率相对减少。生化成份测定结果为矽肺BALF的总蛋白、白蛋白、乳酸脱氢酶(LDH)、β-葡萄糖醛酸酶(β-G)及IgG含量不同程度增高,石棉肺除了Ⅰ期LDH活力升高外,其余指标变化不明显。作者认为BALF的细胞学改变是免疫效应细胞对外来刺激的一种应答,并与随之出现的炎性介质及生化变化有密切关系,可能是肺纤维化形成的基础。
Cytological and biochemical analyzes of bronchoalveolar lavage fluid (BALF) in 72 pneumoconiosis and 19 healthy volunteers were performed. The results showed that the cell concentration of silicosis was significantly higher in the early phase of silicosis (stage Ⅰ) than in the normal control group and in other stages of silicosis. The cell classification showed an increase in the ratio of silicosis lymphocytes (Lym) Also significantly increased; silicosis, asbestos lung alveolar macrophage (PAM) ratio was reduced. The results of biochemical analysis showed that the content of albumin, lactate dehydrogenase (LDH), β-glucuronidase (β-G) and IgG in BALF of silicosis increased to different extents. In addition to the elevated activity of stage I LDH , The remaining indicators change is not obvious. The authors suggest that cytological changes in BALF are a response of immune effector cells to external stimuli and are closely linked to the subsequent inflammatory mediators and biochemical changes that may underlie the formation of pulmonary fibrosis.