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目的：评价乳酸左氧氟沙星治疗ＣＯＰＤ急性发作的临床疗效。方法：在常规治疗的基础上，治疗组４８例用乳酸左氧氟沙星１００～２００ｍ ｇ ｉｖ ｇｔｔｂｉｄ；对照组４７例用氧氟沙星２００ｍ ｇ ｉｖ ｇｔｔｂｉｄ，疗程均为７～１０ｄ。结果：治疗组症状改善有效率为９１．６６％ ，胸片血象好转有效率８９．３６％ ；对照组则分别为５９．５０％ 、５１．０６％ 。两组差异显著（Ｐ＜ ０．０１）。痰培养阳性率分别７２．９２％ 、７０．２１％ ；治疗后细菌清除率分别为９４．２８％ 、７８．７８％ 。不良反应少且轻微。结论：乳酸左氧氟沙星治疗ＣＯＰＤ高效、安全。
Objective: To evaluate the clinical efficacy of levofloxacin lactate in the treatment of acute exacerbation of COPD. Methods: On the basis of routine treatment, 48 cases in the treatment group were treated with levofloxacin 100-200 g gttbid, and 47 cases in the control group were treated with ofloxacin 200 mg g iv gid for 7-10 days. Results: The effective rate of symptom improvement was 91.66% in the treatment group and 89.36% in the chest radiograph. The control group was 59.50% and 51.06% respectively. There was significant difference between the two groups (P <0.01). The positive rates of sputum culture were 72.92% and 70.21% respectively. The bacterial clearance rate after treatment was 94.28% and 78.78% respectively. Adverse reactions and less. Conclusion: Levofloxacin Lactate is effective and safe in the treatment of COPD.