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目的:比较月经间期放置7种宫内节育器(IUD)的使用效果。方法:采用多中心随机比较性的方法,在全国11个省市的42家计划生育服务和医疗机构,对符合本研究纳入标准的观察对象,随机放置TCu220C、TCu380A、母体乐375、宫铜300、宫铜200、元宫药铜220及活性γ型IUD中的一种,比较使用效果和副反应的发生情况。结果:自2004年7月1日～2005年6月30日,共接收观察对象6155例。1年末的随访率为99.5%。7种IUD的带器妊娠率、脱落相关终止率差异有统计学意义,TCu220C、元宫药铜220及活性γ型IUD的使用效果较好,母体乐375和TCu380AIUD的脱落相关终止率较高。结论:我国自行研发的元宫药铜220和活性γ型IUD在带器妊娠、脱落相关、因症终止等诸方面优于其他类型IUD,值得进一步推广使用。
Objective: To compare the effect of using 7 IUDs during menstruation. Methods: Forty-two family planning services and medical institutions in 11 provinces and cities in China were studied. The subjects who met the inclusion criteria of this study were randomly assigned to TCu220C, TCu380A, maternal music 375, Gong Cu 300 , Palace copper 200, Yuan Gong drug copper 220 and active γ-type IUD in a comparison of the use of effects and the incidence of side effects. Results: From July 1, 2004 to June 30, 2005, a total of 6155 subjects were observed. The follow-up rate at the end of 1 year was 99.5%. There were significant differences in pregnancy rate and abortion related rate among 7 kinds of IUDs. The use effect of TCu220C, Yuan Gong Yao Cu 220 and active γ type IUD was better, and the termination rate of maternal music 375 and TCu380AIUD was higher. CONCLUSION: Yuan Gong Yao Cu 220 and active gamma IUD, developed by our country, are superior to other types of IUDs in the aspects of pregnancy, exfoliation and termination due to disease, which are worth further promotion and use.