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目的:探讨胃癌组织FRAT1的表达及其与胃癌各临床病理因素的关系。方法:采用免疫组化、RT-PCR及蛋白质印迹法检测112例胃癌组织和20例癌旁胃黏膜组织中FRAT1的表达及其在不同病理级别胃癌组织中的表达差异。结果:FRAT1mRNA和蛋白在胃癌组织中的阳性表达率为68.8%,明显高于癌旁胃黏膜组织的阳性表达率0,两者比较差异有统计学意义,χ2=30.23,P=0.000。FRAT1在高、中、低分化的胃癌组织中阳性表达率分别为51.6%、72.1%和78.9%,χ2=6.300,P=0.043。且FRAT1的阳性表达与临床分期(P=0.013)和淋巴结转移(P=0.032)有关,而与患者的年龄和性别无关(P>0.05)。结论:FRAT1蛋白的表达率与胃癌的分化程度、TNM分期、淋巴结转移有关,且随着胃癌组织分化程度的增高而降低,随着TNM分期增高而增高。
Objective: To investigate the expression of FRAT1 in gastric cancer and its relationship with clinicopathological factors. Methods: The expressions of FRAT1 in 112 cases of gastric cancer and 20 cases of adjacent tissues of gastric mucosa were detected by immunohistochemistry, RT-PCR and Western blotting. The difference of expression of FRAT1 in different pathological grades of gastric cancer was analyzed. Results: The positive rate of FRAT1 mRNA and protein expression in gastric cancer was 68.8%, which was significantly higher than that in adjacent gastric mucosa (0). The difference was statistically significant (χ2 = 30.23, P = 0.000). The positive rates of FRAT1 in high, moderate and poorly differentiated gastric cancer tissues were 51.6%, 72.1% and 78.9%, respectively, χ2 = 6.300, P = 0.043. The positive expression of FRAT1 was correlated with clinical stage (P = 0.013) and lymph node metastasis (P = 0.032), but not with age and sex (P> 0.05). Conclusion: The expression of FRAT1 protein is correlated with the differentiation of gastric cancer, TNM stage and lymph node metastasis, and decreases with the degree of differentiation of gastric cancer and increases with the increase of TNM stage.