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西咪替丁(cimetidine,CMD)作为一种有效的H_2受体拮抗剂,不仅对于治疗消化性溃疡近期疗效显著,优于一般抗酸解痉药,而且对上消化道出血、胃泌素瘤、糜烂性食管炎、反流性食管炎及某些非消化系统疾病,如带状疱疹也有较好疗效。近年来随着CMD药理学研究的进展,其临床用途日趋广泛,本文综述CMD在儿科的临床应用。 1 药理作用 CMD是一种非硫脲类H_2受体拮抗剂。动物试验显示本品可产生与同量的抑制组胺或五肽胃泌素刺激所致的胃酸分泌作用。应用于病理性胃酸分泌亢进的疾病和荨麻疹等疾患;亦具有抗雄性激素的作用,是二氢睾酮的竞争性抑制药,并有抑制度脂腺分泌的作用;以及免疫调节作用,可增强T淋巴细胞功能及免疫球蛋白浓度。 2 临床应用
As an effective H 2 receptor antagonist, cimetidine (CMD) is not only effective in the short term for the treatment of peptic ulcer, but also superior to the antacid and antispasmodic drugs in general. It also has the effect on upper gastrointestinal bleeding, gastrinoma , Erosive esophagitis, reflux esophagitis and some non-digestive system diseases, such as shingles also have a good effect. In recent years, with the progress of CMD pharmacological research, its clinical use is more and more widely, this article reviews the clinical application of CMD in pediatrics. 1 pharmacological effects CMD is a non-thiourea H 2 receptor antagonist. Animal experiments show that this product can produce the same amount of inhibition of histamine or pentagastrin stimulation of gastric acid secretion. Applied to pathological hypersecretion of gastric acidosis and urticaria and other diseases; also has the role of anti-androgen, is a competitive inhibitor of dihydrotestosterone, and inhibit the secretion of sebaceous glands; and immune regulation can be enhanced T lymphocyte function and immunoglobulin concentration. 2 clinical application