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免疫抑制药环磷酰胺、硫唑嘌呤等虽对一些免疫性疾病有一定的治疗效果,但对淋巴细胞和增殖迅速的肠胃道粘膜、骨髓、毛囊等组织均有毒性,且是诱变致癌剂,所以难以被临床广为接受应用。本文作者合成了一些苯噻喃[4,3-C]吡唑-3-酮类衍生物,并利用小鼠对EI_4肿瘤细胞的体液免疫和细胞免疫反应(小鼠EI_4模型)对其进行免疫抑制试验。试验结果表明,这是一类新型、有效的免疫抑制剂,
Immunosuppressive drugs such as cyclophosphamide, azathioprine, although some of the immune disease has a certain therapeutic effect, but rapid proliferation of lymphocytes and gastrointestinal mucosa, bone marrow, hair follicles and other tissues are toxic, and mutagenic carcinogen , It is difficult to be widely accepted clinical application. The authors synthesized some benzothiopyran [4,3-c] pyrazol-3-one derivatives and immunized mice with humoral and cellular immune responses (mouse EI_4 model) against EI_4 tumor cells Inhibition test. The test results show that this is a new type of effective immunosuppressant,